Friday, October 23, 2009
annotation 2
Citation added: Paul A. Offit, MD. "Vaccine Education Center." Vaccine Education Center. Mar. 2008. The Children's Hospital Of Philadelphia. 23 Oct. 2009 <http://www.chop.edu/service/vaccine-education-center/home. html >.
This article is a secondary source, it was written by Paul A. Offit, MD. By reading this website article, I learned that the vaccine education center sponsored from C.H.O.P. This special center impacted society in a major way because it gives parents information about vaccines they should look into for their children. It explains that an a adult or parent can walk in and get assistance to what vaccines are necessary, how they work, and are they safe. The Children's Hospital Of Philadelphia specifically targets the Children around the world and so does the Vaccine Education Center. This article was targeted for Parents who have young children and kids under the age of 18. I have also learned that The Children's Hospital of Philadelphia, the nation's first children's hospital, has been a center of vaccine research and education for more than 125 years. For example, the rota virus vaccine, a vaccine that prevents the most common cause of vomiting and diarrhea in children, was developed at The Children's Hospital of Philadelphia and the Wistar Institute of Anatomy and Biology.Vaccines have reduced and, in some cases, eliminated many diseases that killed or severely disabled people just a few generations before. For most Americans today, vaccines are a routine part of health care.
annotation 1
http://www.chop.edu/about/our-history/
This website is a secondary source. it was written by the Children's Hospital of Philadelphia. this website helped me find out the history of the hospital and the founder. The article explained how Francis West Lewis, MD came up with the idea of opening the nations first Children's hospital. This hospital was opened for children who were sick because most childhood illnesses were treated at home because infants and children admitted to adult hospitals often died due to cross-infection or neglect. This hospital was founded in 1855. This website could be viewed by people who are during research and people who are looking for physicians, health information, etc.
Monday, October 19, 2009
homework
I found 4 resources for my NHD project
- http://www.stokes.chop.edu/about/overview/
- http://www.chop.edu/about/our-history/
- http://www.cornell.edu
- http://www.ushistory.com
http://www.chop.edu/about/our-history/ helps me with my NHD project because it has specific evidence and it is the primary source
Friday, October 9, 2009
how much money was put into or given to this innovation?
- NIH awards: 379
- Other federal awards: 52
- Non-federal awards: 270
info about Children's Hospital of Philadelphia
Timeline of Research at The Children's Hospital of Philadelphia
- 1855
- The nation's first hospital dedicated exclusively to children is founded by Dr. Francis W. Lewis, with Hewson Bache and R.A.F. Penrose. The 12-bed Hospital treats 63 patients in its first year.
- 1866
- Children's Hospital moves to its second location at 22nd Street between Walnut and Locust. Beds increase to 35.
- 1910s
- “Department for the Prevention of Disease” is established, the first such department in the nation.
- The Hospital relocates to its third building at 18th and Bainbridge Streets. The complex expands over the coming decades.
- 1920s
- Research “Department” is established in the basement at Bainbridge Street – a 14-by-16-foot room with one centrifuge.
- 1930s
- Society of Pediatric Research is founded.
- Discovery of the whooping cough vaccine, the first in a series of vaccines pioneered at Children's Hospital that has worldwide impact on childhood disease.
- 1940s
- Center for Research in Children's Growth is established.
- 1940s-1950s
- Vaccines for influenza and mumps are discovered by husband-and-wife team of Drs. Werner and Gertrude Henle. Additionally, along with Joseph Stokes Jr., MD, they develop the first convincing demonstration of vaccination against influenza and mumps – 100,000 eggs a year were used in the study of viral diseases. They are also the first to prove the effectiveness of gamma globulin in preventing paralytic polio and the first to develop a method to prevent hepatitis.
- 1950s
- “Rheumatic Fever and Virus Research Building” the first research building is built for $800,000, including equipment. It is more commonly known as “The Research Building.”
- Development of a “control shunt” to drain fluid, designed and tested for treating hydrocephalus. This device is now used throughout the world.
- 1950-1960s
- With his research on the prevention of polio, Dr. Lewis L. Coriell begins to lay the groundwork for the development of the Salk vaccine. Dr. Coriell and associates also invent a laminar airflow system to keep operating rooms sterile.
- 1960s.
- The Clinical Research Center (CRC) is established for hard-to-diagnose, hard-to-treat pediatric diseases and use of new treatments. CRC is the forerunner of the General Clinical Research Center, which has been continuously funded by the National Institutes of Health for more than 40 years.
- 1970s
- The Research Institute is created. It includes 70,000 square feet dedicated to research.
- One of the nation's first centers for pediatric craniofacial surgery opens. Techniques for repair of cleft lip and palate developed here gain international acceptance.
- Hospital named by the federal government as one of only three pediatric cancer research and treatment centers.
- The Hospital moves to its current location at 34th Street and Civic Center Boulevard.
- The first DNA Laboratory in Philadelphia is established.
- 1980s.
- General Clinical Research Center establishes a program of scatterbed nurses to extend the reach to the GCRC to the sickest patients – a first among GCRCs.
- Dr. William Carey elected as a member of the Institute of Medicine (IOM).
- Dr. Graham Quinn and associates are coleaders in proving the value of freezing retinal tissue (cryotherapy) to destroy abnormal vessel growth for the prevention of blindness in premature infants.
- A Liver Transplant Program is established. The Hospital's first liver transplant is performed in 1989.
- Early 1990s
- Dr. Stuart E. Starr shows that a combination of antiviral drugs provides strong, sustained control of HIV infection in children.
- Drs. John Maris, Eddie Attiyeh and Garrett Brodeur identified three genetic abnormalities that are characteristic of certain neuroblastomas. The presence of these genetic changes can predict outcome and help the treating physicians select the most appropriate intensity of therapy for these patients.
- The Hospital is designated a Human Genome Center by the National Institutes of Health and awarded a major federal grant for the mapping of chromosome 22 (completed in 1999).
- Dr. Terri Finkel and colleagues are the first to show that HIV does more than infect T cells. The virus also seems to prime uninfected T cells for suicide, reducing the ability to fight infection. They are also the first to show that HIV renders some of the cells it infects death-resistant, thereby prolonging the life span of these virus factories.
- 1995
- The Leonard and Madlyn Abramson Pediatric Research Center opens on the Hospital's Main Campus, consolidating all the laboratory research of The Children's Hospital of Philadelphia Research Institute.
- The Division of Gastroenterology and Nutrition is at the forefront in the identification, diagnosis and treatment of Eosinophilic Esophagitis (EoE) — a new allergic GI disease in children.
- 1997
- Drs. Nancy Spinner, David Piccoli and Ian D. Krantz discover the gene responsible for Alagille syndrome, a disorder associated with congenital liver, heart, kidney, spine, eye and pancreatic disease..
- Dr. Michael Grunstein and colleagues are the first to demonstrate that a receptor for IgE is present in airway smooth muscle, making it asthmatic in nature. They further found that a protein that is also present in airway smooth muscle can protect it from developing an asthmatic response.
- Drs. Flaura K. Winston and Dennis R. Durbin initiate Partners for Child Passenger Safety. Their research shows that young children who use age appropriate restraints, such as a booster seats, have a 59 percent lower risk of injury in a crash. They also show that rear seats of compact extended cab pick-up trucks are particularly dangerous. These findings lead to a wide range of enhanced legislation, safety regulation, and automobile and child restraint design.
- 1998
- Children's Clinical Research Institute (CCRi) is established as the nation's first non-profit comprehensive clinical research organization dedicated to pediatric clinical trials.
- Steven Ludwig, MD, and N. Scott Adzick, MD, are elected as members of the Institute of Medicine (IOM).
- 1999
- Dr. Beverly Emanuel's efforts contribute to the complete sequencing of chromosome 22, making it the first human chromosome to be fully sequenced. Defects in genes on chromosome 22 are implicated in certain leukemias and other pediatric tumors, mental retardation, numerous birth defects and the 22q11 deletion syndrome.
- Based on Dr. Katherine High's groundbreaking studies on AAV-mediated gene transfer for hemophilia, Dr. Catherine Manno and Dr. Alan Flake perform the first human gene transfer studies for hemophilia B using an AAV vector expressing Factor IX in people with hemophilia.
- The Clinical Trials Office (CTO) is established to facilitate clinical research studies conducted at Children's Hospital.
- Children's Hospital becomes one of 13 academic sites designed by the NIH as a Pediatric Pharmacology Research Unit (PPRU). PPRUs are established to conduct studies of drug disposition and action in pediatric patients, and address the lack of pharmacological information about drugs used in children.
- 2001
- The Hospital begins a $1.2 billion facilities expansion in response to enormous demand for services. The project will nearly double the size of the main campus, adding significant patient care and research space.
- Dr. Beverly Lange and associates devise a strategy that has about a 70 percent salvage rate for recurring acute lymphoblastic leukemia. This has been successful in getting children into remission until another therapy (e.g., bone marrow transplant) is available.
- 2002
- The first tandem transplantation of peripheral stem cells performed in a pediatric oncology center.
- Dr. Alan Flake, along with his colleagues, achieves high levels of donor cell engraftment after in utero transplantation of hematopoietic stem cells into mice. This is associated with donor specific tolerance which allows postnatal boosting to 100 percent donor cell engraftment without toxicity or graft vs. host disease (GVHD).
- 2004
- Dr. Ian Krantz leads a team that identifies the gene that causes Cornelia de Lange syndrome, (CdLs) which leads to a genetic test. CdLs symptoms include mental retardation, growth failure, hearing loss, and physical defects affecting the limbs, face, heart, intestines and other structures.
- 2005
- Dr. Vivian Cheung identifies genomic regions that contain the transcriptional regulators for about 1,000 genes. These results provide a better understanding of transcriptional regulation in human cells and may be applicable for discovering the genetic basis of other complex human traits and diseases.
- The Children's Hospital of Philadelphia celebrates its 150th anniversary.
- 2006.
- The Hospital breaks ground for a $400 million, state-of-the-art research facility dedicated to translational research.
- Dr. Robert J. Levy shows that gene vectors can be delivered from the bare metal surfaces of stents without a polymer coating, a finding that could prove useful for virtually any metallic prosthesis and decrease the chances of an inflammatory response.
- 2007
- Drs. Paul Offit, H Fred Clark and Stanley Plotkin are awarded the Gold Medal of The Children's Hospital of Philadelphia-the Hospital's highest honor-for their work on the rotavirus vaccine.
- Children's Hospital and the University of Pennsylvania began collaboration for a Clinical and Translational Science Award center, part of a nationwide effort to transform translational biomedical research.
http://stokes.chop.edu/about/timeline/
C.H.O.P hospital (Mission and Vision)-advance the health of children by turning scientific discovery into medical innovation.
- All research activities at Children's Hospital are administratively organized under the aegis of the CHOP Research Institute.(mission)
- The Children's Hospital of Philadelphia Research Institute is world-renown, leading research breakthroughs and medical innovations for more than 80 years. The Institute continues its dedication to translating innovative research findings to outstanding patient care.(vision)
- The Children's Hospital of Philadelphia Research Institute is home to one of the largest pediatric research programs in the country with more than $100 million in total federal awards and an annual budget of more than $200 million
- With a phenomenal increase in research staff, space and external funding, doubling twice in the past decade alone and exceeding the growth of the NIH's extramural budget, the Research Institute at Children's Hospital continues to build upon its rich research history and continue its pursuit to improve the health of children throughout the world.
http://stokes.chop.edu/about/overview/
Thursday, October 8, 2009
National History Day

Children's Hospital in Philadelphia
- children's hospital was founded in 1855.
- most childhood illnesses were treated at home because infants and children admitted to adult hospitals often died due to cross-infection or neglect.
- After visiting the Great Ormond Street Hospital for Sick Children in London, Francis West Lewis, MD, decided to create a hospital in the United States dedicated to finding cures and treating illnesses and injuries specific to children
- In the Hospital's first year, it had 12 beds and a dispensary, and the physicians served 67 inpatients and 306 clinic patients.
- On June 23, 1974, the Hospital moved all its equipment and patients to its current location at 34Th Street and Civic Center Boulevard in West Philadelphia.
- Over the years, the Hospital added the The Childrens Hospital of Philadelphia Research Institute, one of the largest pediatric research facilities in the United States, and acquired Children's Seashore House, a comprehensive pediatric rehabilitation center.
- From 1855 on, Children's Hospital has remained true to our founders' vision, nurturing some of the nation's pioneers and innovators in pediatric medicine and contributing a number of firsts to the field.
- Today, the Hospital has 430 beds and had more than 1 million outpatient and inpatient visits last year.
http://www.chop.edu/about/our-history/
study island
Tuesday, October 6, 2009
Service learning
Service Learning- 3 ideas for service learning
- raise money for shelters by having a candy sale and having raffles.
- have a movie night and raise money for the homeless.
- have dress down days, etc. raise money for adoption homes
National History Day
National History Day
- What is your topic? the first public hospital in philadelphia.
- When was your innovation invented or thought of? • The Pennsylvania Hospital, founded by Benjamin Franklin and Thomas Bond, opened its doors in 1751 - the first hospital in America. In addition, Philadelphia is home to the nation's first medical school, first children's hospital, first cancer hospital, first eye hospital, first nursing school and first dental school.
- What was happening in the country/world at that time (social, political, economic)? something that was going on in this time period was that on February 7 The Pennsylvania Hospital, the first establishment in North America devoted to the relief of the sick and suffering, was chartered by the Assembly of Pennsylvania, at the solicitation of Benjamin Franklin, Dr. Thomas Bond, Rev. Richard Peters and others.
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